Over the last five years, scientist have discovered through a chain reaction of metabolic event that elevated levels of insulin in the bloodstream increase blood levels of a hormone called "insulin like growth factor one " (IGF-1) and decrease another hormone called "insulinlike growth factor binding protein three" (IGFBP-3). The decrease in IGFBP-3 causes tissues to be less sensitive to one of the body's natural chemicals signals (retinoic acid) that normally limits tissue growth. In addition, IGF-1, a potent hormone in all tissues, is a major regulator of growth: increased levels of IGF-1 encourages growth, and reduced levels slow growth. Children who are below normal height have low levels of IGF-1. When IGF-1 is injected into these children, they immediately start to grow taller. As you might expect, tall children have higher levels of IGF-1.
Diets that cause insulin resistance-particularly, high glycemic carbohydrate diets-increase IGF-1 levels, lower IGFBP-1 levels, and decrease tissue sensitivity to retonic acid. There hormonal changes, in turn, accelerate growth in developing children.
What does this have to do with adult health? Its been found that IGF-1 is a powerful stimulator of cell division-growth- in all cells during all phases of life. In fact, scientist suspect that IGF-1 may be one of the primary promoters of all unregulated and tissue growth in the body. But IGFBP-3 prevent unregulated cell growth by causing cancer cell to die naturally through a process called "apoptosis". Over the last decade, numerous scientific papers have shown a strong association between elevated levels of IGF-1, lowered level of IGFBP-3, and breast cancer in premenopausal women, prostate cancer in men, and colorectal cancer in all adults. In animal model of many types of cancer, scientist can promote cancer by adding a key ingredient - IGF-1; conversely adding IGFBP-3 slows cancer. So, the whole chain of hormonal events initiated by elevated blood levels of insulin tends to promote the cancer processThe Paleo diet (Revised Edition), lose weight and get healthy by eating the foods you were designed to eat, Loren Cordain, Ph.D., John Wiley & Sons, Inc., Pag. 80-82, Par, 4
High consumption of refined grains or grains in general, sugars and process food that are unnatural for are genetics will always cause harm. Eliminating these foods for your daily diet would be the best thing that you can do for your health.