Wednesday, July 18, 2012

Cannabinoids: A new hope for breast cancer therapy?

Cannabinoids: A new hope for breast cancer therapy?

Source

Dept. Biochemistry and Molecular Biology I, School of Biology, Complutense University-CIBERNED-IRYCIS, Madrid, Spain.

Abstract

Breast cancer is a very common disease that affects approximately 1 in 10 women at some point in their lives. Importantly, breast cancer cannot be considered a single disease as it is characterized by distinct pathological and molecular subtypes that are treated with different therapies and have diverse clinical outcomes. Although some highly successful treatments have been developed, certain breast tumors are resistant to conventional therapies and a considerable number of them relapse. Therefore, new strategies are urgently needed, and the challenge for the future will most likely be the development of individualized therapies that specifically target each patient's tumor. Experimental evidence accumulated during the last decade supports that cannabinoids, the active components of Cannabis sativa and their derivatives, possess anticancer activity. Thus, these compounds exert anti-proliferative, pro-apoptotic, anti-migratory and anti-invasive actions in a wide spectrum of cancer cells in culture. Moreover, tumor growth, angiogenesis and metastasis are hampered by cannabinoids in xenograft-based and genetically-engineered mouse models of cancer. This review summarizes our current knowledge on the anti-tumor potential of cannabinoids in breast cancer, which suggests that cannabinoid-based medicines may be useful for the treatment of most breast tumor subtypes.

2 comments:

Unknown said...

Obtain an ounce or more of cannabis leaf ("shake") or flower tops ("marijuana"). Cook on low heat in coconut oil for 8-10 hours, with a ratio of 1-2 ozs. of cannabis for each 1/2 litre of coconut oil. Strain the coconut oil through cheesecloth. Allow to cook to room temperature and use the resulting coconut butter topically or orally. Rub on and around the tumor site and eat 1 tbs. 2-3 times per day. This is a treatment for cancer. The more butter you have, the more you should rub it all over your body, but especially at the tumor site. Good luck.

Unknown said...

Correction: "allow to cool to room temperature" not "cook to room temperature."